EGF CLIA Kit for Human(Homo sapiens) | EIAab.comEGF CLIA Kit for Human(Homo sapiens)

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Index > Protein center > EGF(Gene name) > Human

EGF (Gene name),

Pro-epidermal growth factor (Protein name ), EGF_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (1)

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Gene name:

EGF;

Protein name:

Pro-epidermal growth factor(EGF);

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with EGFR and promotes EGFR dimerization. Interacts with RHBDF2 (By similarity). Interacts with RHBDF1; may retain EGF in the endoplasmic reticulum and regulates its degradation through the endoplasmic reticulum-associated degradation (ERAD).

Function:

EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.

Subcellular Location:

Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

1207

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

1000:

1050:

1100:

1150:

1200:

1207:

HQMELTQ

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P01133

Pfam:

PF00008

STRING:

9606.ENSP00000265171

MIM:

131530

UniGene:

Hs.419815

SMR:

P01133

KEGG:

hsa:1950

Uniprot:

P01133

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ELISA Kit for Human EGF

Cat.:

E0560h

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96T

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ELISA Kit for Human EGF

Cat.:

E0560d

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96T

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ELISA Kit for Human EGF

Cat.:

E0560m

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96T

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ELISA Kit for Human EGF

Cat.:

E0560r

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96T

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ELISA Kit for Human EGF

Cat.:

E0560p

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96T

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CLIA Kit for Human EGF

Cat.:

U0560p

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Packing:

96T

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CLIA Kit for Human EGF

Cat.:

U0560r

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Packing:

96T

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CLIA Kit for Human EGF

Cat.:

U0560m

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Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Human EGF

Cat.:

U0560d

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Looking for manual.

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Packing:

96T

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CLIA Kit for Human EGF

Cat.:

U0560h

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96T

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Polyclonal Antibody for Human EGF

Cat.:

P0560Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human EGF

Cat.:

P0560Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human EGF

Cat.:

P0560Rb-r

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human EGF

Protein for Human EGF

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

Intra-Assay CV: ≤4.3

Inter-Assay CV: ≤7.5

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Citations

[1].

"Dexmedetomidine causes neuroprotection via astrocytic α 2-adrenergic receptor stimulation and HB-EGF release"

Meixia Zhang, Xiaolei Shan, Li Guv, Leif Hertz and Liang Peng

From:Journal of Anesthesiology & Clinical Science

References

1.

"Human epidermal growth factor precursor: cDNA sequence, expression in vitro and gene organization."
Bell G.I. , Fong N.M. , Stempien M.M. , Wormsted M.A. , Caput D. , Ku L. , Urdea M.S. , Rall L.B. , Sanchez-Pescador R.
Nucleic Acids Res.14:8427-8446(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Kidney.
2.

NIEHS SNPs program
Submitted (2003-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ARG-16; HIS-257; LYS-431; ARG-638; ILE-708; VAL-784; THR-842; VAL-920; GLU-981; PHE-1043 AND GLY-1084
3.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANT VAL-920
tissue: Teratocarcinoma.
4.

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Colon.
6.

"The primary structure of human urogastrone."
Gregory H. , Preston B.M.
Int. J. Pept. Protein Res.9:107-118(1977) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 971-1023
7.

"The primary structure of human EGF produced by genetic engineering, studied by high-performance tandem mass spectrometry."
Furuya M. , Akashi S. , Hirayama K.
Biochem. Biophys. Res. Commun.163:1100-1106(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 971-1023
8.

"Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."
Halim A. , Nilsson J. , Ruetschi U. , Hesse C. , Larson G.
Mol. Cell. Proteomics0:0-0(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT SER-954 AND THR-955;STRUCTURE OF CARBOHYDRATES;IDENTIFICATION BY MASS SPECTROMETRY
9.

"Human epidermal growth factor. High resolution solution structure and comparison with human transforming growth factor alpha."
Hommel U. , Harvey T.S. , Driscoll P.C. , Campbell I.D.
J. Mol. Biol.227:271-282(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF EGF
10.

"Impaired basolateral sorting of pro-EGF causes isolated recessive renal hypomagnesemia."
Groenestege W.M.T. , Thebault S. , van der Wijst J. , van den Berg D. , Janssen R. , Tejpar S. , van den Heuvel L.P. , van Cutsem E. , Hoenderop J.G. , Knoers N.V. , Bindels R.J.
J. Clin. Invest.117:2260-2267(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;VARIANT HOMG4 LEU-1070;CHARACTERIZATION OF VARIANT HOMG4 LEU-1070
11.

"Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling."
Zettl M. , Adrain C. , Strisovsky K. , Lastun V. , Freeman M.
Cell145:79-91(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RHBDF1
12.

"Crystal structure of human epidermal growth factor and its dimerization."
Lu H.S. , Chai J.J. , Li M. , Huang B.R. , He C.H. , Bi R.C.
J. Biol. Chem.276:34913-34917(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 971-1021;DISULFIDE BONDS
13.

"Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains."
Ogiso H. , Ishitani R. , Nureki O. , Fukai S. , Yamanaka M. , Kim J.H. , Saito K. , Sakamoto A. , Inoue M. , Shirouzu M. , Yokoyama S.
Cell110:775-787(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF 971-1023 IN COMPLEX WITH EGFR;DISULFIDE BONDS
14.

"EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization."
Ferguson K.M. , Berger M.B. , Mendrola J.M. , Cho H.S. , Leahy D.J. , Lemmon M.A.
Mol. Cell11:507-517(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 971-1023 IN COMPLEX WITH EGFR;DISULFIDE BONDS
15.

"The NMR solution structure of human epidermal growth factor (hEGF) at physiological pH and its interactions with suramin."
Huang H.W. , Mohan S.K. , Yu C.
Biochem. Biophys. Res. Commun.402:705-710(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 971-1023 IN COMPLEX WITH SURAMIN
16.

"Structural evidence for loose linkage between ligand binding and kinase activation in the epidermal growth factor receptor."
Lu C. , Mi L.Z. , Grey M.J. , Zhu J. , Graef E. , Yokoyama S. , Springer T.A.
Mol. Cell. Biol.30:5432-5443(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF 975-1021 IN COMPLEX WITH EGFR;DISULFIDE BONDS

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